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TBC1D4 (TBC1 Domain Family Member 4, Akt Substrate of 160kD, AS160, KIAA0603)

TBC1D4 (TBC1 Domain Family Member 4, Akt Substrate of 160kD, AS160, KIAA0603)

Cat no: T1501-04C

Supplier: United States Biological
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TBC1D4 may act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of cell lines daudi and MOLT4 on ~150kD bands Immunohistochemistry (Paraffin): 3-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T1501-04C
Reactivities: Human, Canine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. Diabetes. 2005 Jun;54(6):1692-7.
Additional info: Recognizes human TBC1D4. Species sequence homology: Canine.

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