TCF-4 Antibody

Cat no: 252141

Supplier: ABBIOTEC

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Description
Additional Information

T-cell-specific transcription factor 4 (TCF-4) participates in the Wnt signaling pathway and modulates MYC e, Xenopus/Amphibian,pression by binding to its promoter in a sequence-specific manner. TCF-4 acts as repressor in the absence of CTNNB1, and as activator in its presence. TCF-4 activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. E, Xenopus/Amphibian,pression of dominant-negative TCF-4 mutants results in cell-cycle arrest in G1. Genetic variations in TCF-4 are associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM). NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.

Catalogue number:	252141
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	Q9NQB0
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TCF-4.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Transcription factor 7-like 2; HMG bo, Xenopus/Amphibian, transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4; TCF7L2; TCF4