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TCF1 (Hepatocyte Nuclear Factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific Transcription Factor LF-B1, LFB1, Transcription Factor 1, TCF-1, HNF1A)

Cat no: T2020-20C

TCF1 (Hepatocyte Nuclear Factor 1-alpha, HNF-1-alpha, HNF-1A, Liver-specific Transcription Factor LF-B1, LFB1, Transcription Factor 1, TCF-1, HNF1A)

Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:4000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T2020-20C

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Can

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Hansen SK, Parrizas M, Jensen ML, Pruhova S, Ek J, Boj SF, Johansen A, Maestro MA, Rivera F, Eiberg H, Andel M, Lebl J, Pedersen O, Ferrer J, Hansen T. Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function. J Clin Invest. 2002 Sep;110(6):827-33.

Additional Info

Recognizes HNF1A. Species sequence homology: Canine, human, mouse and rat.

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