Home  >  Products  >  TCF7L2 (Transcription Factor 7-like 2, HMG Box Transcription Factor 4, T-cell-specific Transcription Factor 4, T-cell Factor 4, TCF-4, hTCF-4, TCF4)
TCF7L2 (Transcription Factor 7-like 2, HMG Box Transcription Factor 4, T-cell-specific Transcription Factor 4, T-cell Factor 4, TCF-4, hTCF-4, TCF4)

TCF7L2 (Transcription Factor 7-like 2, HMG Box Transcription Factor 4, T-cell-specific Transcription Factor 4, T-cell Factor 4, TCF-4, hTCF-4, TCF4)

Cat no: T8195-43

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
TCF4 (T cell factor 4; also known as TF7L2) serves as transcriptional activator affecting e.g. cell cycle and terminal cell differentiation. In the absence of Wnt signals, TCF4 interacts with TLE/Groucho corepressor, supressing the transcription of TCF4 target genes. Wnt signaling leads to stabilisation and accumulation of beta-catenin, which binds TCF4 N-terminus, whereas TCF4 C-terminal HMG-box domains interact with DNA. Cell death-associated Daxx protein or plakoglobin belong to negative regulators of TCF4-mediated transcription, on the other hand, there is a positive feedback loop of beta-catenin-TCF4 pathway comprising the p300 coactivator. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Immunocytochemistry: 1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8195-43
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 15mM sodium azide, pH 7.4.
P type: Pab
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human TCF7L2. Species sequence homology: Mouse.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave