TCF8 Antibody

Cat no: 252082

Supplier: ABBIOTEC

0 reviews | Write a Review Pencil

Description
Additional Information

Zinc finger E-bo, Xenopus/Amphibian,-binding homeobo, Xenopus/Amphibian, 1 (TCF8) inhibits interleukin-2 (IL-2) gene e, Xenopus/Amphibian,pression. TCF8 is responsible for transcriptional repression of the IL-2 gene. TCF8 enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. TCF8 represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Defects in TCF8 are the cause of posterior polymorphous corneal dystrophy type 3 (PPCD3). PPCD is a rare disease involving metaplasia and overgrowth of corneal endothelial cells. In patients with PPCD, these cells manifest in an epithelial morphology and gene e, Xenopus/Amphibian,pression pattern,Porcineroduce an aberrant basement membrane, and, sometimes, spread over the iris and nearby structures in a way that increases the risk for glaucoma.

Catalogue number:	252082
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 mg
Accession:	P37275
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TCF8.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Zinc finger E-bo, Xenopus/Amphibian,-binding homeobo, Xenopus/Amphibian, 1; Transcription factor 8; TCF-8; NIL-2-A zinc finger protein; Negative regulator of IL2; ZEB1; AREB6; TCF8