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TCR, gamma, delta (T Cell Receptor) (PE)

Cat no: T2040-05V

TCR, gamma, delta (T Cell Receptor) (PE)

The gd T cell receptor complex (TCR) is an eight subunit heteromer that consists of one gamma TCR and one delta TCR chain, a TCR zeta chain homodimer, a CD3g:CD3e heterodimer, and either a second CD3g:CD3e heterodimer or a CD3g:CD3e heterodimer. All possible subunits are members of the Ig superfamily, save for the TCR zeta chains. The 55kD TCR-g and 40kD TCR-d chains are amalgams of the products of multiple genes, which in the case of TCR-d include a gene coding for a variable region, a diversity region, a joining segment and a constant region. The constant region C gene itself has four structural segments, an extracellular region with a C1 (or C2) Ig-like domain, a connecting peptide, a transmembrane segment and a cytoplasmic tail. The TCR-z chains, plus the CD-3d:CD3e heterodimer and, possibly, the CD3g: CD3e heterodimer all interact with the TCR-d chain transmembrane segment. Depending upon the nature of the C region Ig-like domain, the TCR subunits may or may not be disulfide-linked. In mice, the extracellular region of the C gene (87aa) shares 95% and 82% aa sequence identity with rat and human C gene extracellular regions.\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nAbsorption: 488nm\n\nEmission: 565-605nm\n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

T2040-05V

Size

100Tests

Applications

FC

Reactivities

Mouse

Form

Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG2

Additional Info

Recognizes mouse TCR g/d.

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