TCR, gamma, delta (T Cell Receptor) (PE)

The TCR gamma, delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains.1 It is expressed during thymopoiesis and on the small subpopulation of gamma, delta TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma, delta+ and have limited receptor diversity.1, 2 The TCR gamma, delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation.3\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

T2040-06J

Size

100ug

Applications

FC, IHC, IP

Reactivities

Mouse

Form

Supplied as a liquid in PBS, 0.1% sodium azide and a stabilizing agent. Conjugated to PE.

P Type

Mab

Purity

Purified

Isotype

IgG

References

1. Davis, M.M. 1990. Annu. Rev. Biochem. 59:475.\n2. Allison, J.P., and W.L. Havran. 1991. Annu. Rev. Immunol. 9:679.\n3. Klausner, R.D., and L.E. Samuelson. 1991. Cell 64:875.\n4. Dent, A.L., et al. 1990. Nature 343:714.\n5. Bluestone, J.A., et al. 1991. Immunol. Rev. 120:5.\n6. Houlden, B.A., et al. 1989. Cold Spring Harbor Symp. Quant. Biol. 54:45.\n7. Barrett, T.A., et al. 1991. Immunol. Res. 10:341.

Additional Info

Recognizes gamma/delta T-cell receptor (TCR) complex. Specific for the gamma, delta heterodimer and plate-bound antibody activates gamma, delta TCR-bearing cells. Does not react with alpha, beta TCR-expressing T cells.