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TCR, gamma, delta (T Cell Receptor)

Cat no: T2040-06

TCR, gamma, delta (T Cell Receptor)

This antibody precipitates a heterodimer of Mr 90kD (two bands of Mr 40kD and 50kD upon reduction) on chicken peripheral blood T cells.1,2 Deglycosylation of the heterodimer yields two polypeptides of Mr 35kD and 32kD from antibody precipitates. Unlike human and mouse, in which gamma/delta cells comprise a minor subset of T lymphocytes in the circulation, the chicken has a relatively large subset of gamma/delta T cells.1-3 The frequency of TCRgd cells is usually 20-25% of the total blood T cells, but may reach approximately 50% in chickens of 12 months of age.2 The majority of TCRgd+ cells in the thymus and blood are CD4-CD8-, although a small subset of them may express CD8 or CD4 coreceptors.3 However, when the TCRgd+ cells migrate into the spleen and intestine, most of them begin to express CD8. Although the biological function of gd T cells is unclear, they are clearly capable of cytotoxic activity in vitro. The CD8+ gd T cells may also be involved in down-regulation of the immune response.4 They cannot, however, induce a graft-vs-host (GVH) reactions.5\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

T2040-06

Size

500ug

Applications

FC, IHC, IP

Hosts

Mouse

Reactivities

Ch/Bird

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.0. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG1,k

References

1. Sowder, J.T., C.-L. Chen, L.L. Ager, M.M. Chan, and M.D. Cooper. 1988. J. Exp. Med. 167:315.\n2. Chen, C.H., J. Cihak, U. L

Additional Info

Recognizes chicken TCR gamma, delta.

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