TDO (Tryptophan 2,3-dioxygenase) incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.
Biological Activity:
Enzymatic activity of recombinant human TDO (heme-free) at 450nm (see Figure 1).
Enzymatic activity of recombinant human TDO (heme-free) at 480nm (see Figure 2).
Sequence:
Human TDO (aa 2-406) is fused at the N-terminus to a His-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Stable for at least 1 year after receipt when stored at -20 degrees C. Working aliquots are stable for up to 3 months when stored at -20 degrees C.