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TEM7R, NT (Plxdc2, Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein)

Cat no: T2500-02

TEM7R, NT (Plxdc2, Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein)

Plxdc2, also known as Tumor endothelial marker 7-related (TEM7R) encodes a protein with 57% amino acid identity to TEM7, the most abundant tumor endothelial marker (1,2). Plxdc2 is strongly expressed in the endothelial cells of the tumor stroma, but not in the endothelial cells of normal colonic tissue. Plxdc2 is also expressed at high levels in vessels of some normal tissues, with highest expression in muscle and lung (1). Plxdc2 and TEM7 may be important for tumor angiogenesis in humans (2,3). Cortactin was identified as a protein capable of binding to the extracellular region of both TEM7 and Plxdc2, and may provide new opportunities for the delivery of therapeutic and imaging agents to the vessels of solid tumors (4).\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5

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SPECIFICATIONS

Catalog Number

T2500-02

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Carson-Weber EB, Watkins DN, Nanda A, et al. Cell surface tumor epithelial markers are conserved in mice and humans. Cancer Res. 2001; 61:6649-55. 2. Nabda A and St. Croix Bl. Tumor endothelial markers: new targets for cancer therapy. Curr Opin Oncol. 2004; 16:44-9. 3. St. Croix B, Rago C, Velculescu V, et al. Genes expressed in human tumor endothelium. Science 2000; 289:1197-202. 4. Nanda A, Buckhaults P, Seaman S, et al. Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R. Cancer Res. 2004; 64:8507-11.

Additional Info

Recognizes human Plxdc2. Species crossreactivity: Mouse and rat.

Read more on Supplier website

Applications

ELISA, FC, IHC, WB

Hosts

Rabbit

Reactivities

Hum

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