Terlipressin

Terlipressin is similar to a naturally occurring hormone present in the body, known as antidiuretic hormone (ADH) or vasopressin. ADH has two main effects in the body. Firstly, it causes narrowing of blood vessels (vasoconstriction), thereby limiting blood flow to a particular area of the body. It also acts on receptors in the kidney to retain water in the body, which helps to prevent excessive loss of water in the urine. Terlipressin is commonly used to stop bleeding of varices in the food pipe (oesophagus). Varices are fragile distended veins that can occur in various parts of the body such as the oesophagus. This is caused by an increase in blood pressure in certain diseases such as severe liver disease. These fragile varices can rupture and lead to life threatening bleeding. Terlipressin is therefore given to narrow blood vessels, and so restricting blood flow to the varices and stopping the bleeding. Terlipressin contains 12 amino acids Gly-Gly-Gly-c[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2 and having a molecular weight of 1227.4.\n\nEndotoxin: \n(same/less than) 0.1ng/ug (IEU/ug) of Terlipressin.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Reconstitute to nominal volume \n(see reconstitution instructions for peptides) and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.\n

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SPECIFICATIONS

Catalog Number

T2735-25

Size

50mg

Form

Supplied as a lyophilized powder without additives.

Purity

(same/more than) 98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Treatment of hepatic hydrothorax with terlipressin in a cirrhotic patient.\n\nScand J Gastroenterol 2006 Jul;41(7):862-5\n\n2. Best evidence topic report. The use of intravenous terlipressin in non-variceal upper GI bleeds.\n\nEmerg Med J 2006 May;23(5):400-1\n\n3. Rescue therapy in septic shock - is terlipressin the last frontier?\n\nCrit Care 2006 Mar 21;10(2):131\n\n4. Comparison of arginine vasopressin, terlipressin, or epinephrine to correct hypotension in a model of anaphylactic shock in anesthetized brown Norway rats.\n\nAnesthesiology 2006 Apr;104(4):734-41\n\n5. Best evidence topic report. Terlipressin or sclerotherapy for acute variceal bleeding?\n\nEmerg Med J 2006 Apr;23(4):301\n\n6. Terlipressin for refractory hypotension following angiotensin-II receptor antagonist overdose.\n\nAnaesthesia 2006 Apr;61(4):408-9