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Tetanus Toxin, Clostridium tetani, Light Chain (Clostridium tetani Toxoid, Tetanus Toxoid, Tentoxylysin, tetX)

Cat no: T2962-01E

Tetanus Toxin, Clostridium tetani, Light Chain (Clostridium tetani Toxoid, Tetanus Toxoid, Tentoxylysin, tetX)

Tetanus toxin, a member of the peptidase M27 family of proteins, is produced by the anaerobic spore-forming bacteria Clostridium tetani as a single-chain polypeptide that is 1315aa in length. The protein is subsequently cleaved by an endogenous protease to yield the 52kD tetanus toxin light chain (TeNT-LC), which is 457aa in length, and the 98kD tetanus toxin heavy chain that is 858aa long. The light and heavy chains are linked by a disulfide bridge and are non-toxic after separation. Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neural synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the

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SPECIFICATIONS

Catalog Number

T2962-01E

Size

100ug

Hosts

Mouse

Form

Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.

P Type

Mab

Purity

Purified by Protein A/G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes Tetanus toxin, light chain. No cross-reactivity with recombinant TeNT Heavy Chain.

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