TGFbeta RII (I122) Peptide

A total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

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SPECIFICATIONS

Catalog Number

BS1360P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide TGFbeta RII (I122). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P37173

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1360 TGFbeta RII (I122) pAb.

Alternative Names

TGF-beta receptor type-2; TGFR-2; TGFR2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II; TGFBR2