Home  >  Products  >  TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H)
TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H)

TGM2 (TGase-2, Transglutaminase-2, TGC, Protein-glutamine gamma-glutamyltransferase 2, Tissue Transglutaminase, Transglutaminase C, TG(C), TGase C, Transglutaminase H, TGase H)

Cat no: T8260-03M

Supplier: United States Biological
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Transglutaminase(TGase) catalyses the crosslink of proteins by forming -(-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal -sandwich, catalytic core and two C-terminal -barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including A peptide, -amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000-1:5000 Optimal dilutions to be determined by the researcher. Positive Control: U87MG Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8260-03M
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in HEPES, 0.15M sodium chloride, 0.01% BSA, 0.03% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Griffin, M. et al. (2002) Biochem. J. 368, 377-396. 2. Fesus, L. and Piacentini, M. (2002) Trends. Biochem. Sci. 27(10), 534-539. 3. Kim, SY. et al. (2002) Neurochem. Int. 40, 85-103.
Additional info: Recognizes human TGM2.

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