Th-POK (ZFP67) is a transcription regulator that acts as a key regulator of lineage commitment of immature T cell precursors. It is necessary for commitment of CD4 lineage, while its absence causes CD8 commitment. It is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Sequence:
Human Th-POK (aa 1-539) is fused at the C-terminus to a His-tag.
Storage and Stability:
Short-term Storage: +4 degrees C
Long-term Storage: -20 degrees C
Working aliquots are stable for up to 3 months when stored at -20 degrees C.