Supplier:
Alomone Labs Ltd.Cat no: T-650
Thapsigargin
Thapsigargin, derived from the plant genus Thapsia is an extremely tight-binding inhibitor of intracellular Ca2+пїЅpumps. It was initially described as a tumor promoting agent which induces rapid Ca2+пїЅrelease from intracellular stores by inhibition of the sarcoplasmic/endoplasmic reticulm Ca2+-dependent ATPase pump without inositol phosphate formation. The thapsigargin induced depletion of Ca2+пїЅstores causes apoptosis in most cell lines. It has also been shown to cause histamine secretion from rat mast cells, and to stimulate arachidonic acid metabolism in macrophages. Its tumour-promoting function probably results, at least partly, from cytotoxicity, causing a wound response in skin. The tumorogenic activity of thapsigargin might be due to its activation of protein kinase B (Akt) which subsequently stimulates MAP kinase signaling via Src and Raf-1. Cell Signaling Activators and Inhibitors; Apoptosis Inducers, Cell Ca2+ Signaling > Intracellular Ca2+ Mobilizers
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SPECIFICATIONS
Catalog Number
T-650
Size
5 x 0.65 mg
Purity
>99%
Concentration
0 nM - 1 micro M.
Shipping Temp
Room Temperature
Molecular Weight
650.7
SUPPLIER INFO
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