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Thapsigargin

Cat no: T3705

Thapsigargin

Potent, cell permeable IP3-independent intracellular calcium releaser.\n\nSolubility:\nSoluble in DMSO or ethanol.\n\nStorage and Stability:\nMay be stored at RT for short-term only. Long-term storage is recommended at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T3705

Size

1mg

Form

Supplied as a colorless or water-white powder.

Purity

~99%

References

1. Takemura, H., et al. \"Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane.\" J. Biol. Chem. 264:12266-12271 (1989). 2. Thastrup, O., et al. \"Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage.\" Agents Actions 27:17-23 (1989). 3. Rasmussen, U.S.B., et al. \"Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica\" Acta Pharm. Suecica 15:133-140 (1978). 4. Patkar, S.A., et al. \"On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L.\" Agents Actions 9:53-57 (1979). 5. Hakii, H., et al. \"Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis.\" J. Cancer Res. Clin. Oncol. 111:177-181 (1986). 6. Ohuchi, K., et al. \"Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter.

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