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Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2)

Cat no: T5010-16M

Thioredoxin Reductase 2, SelCys523Cys, Recombinant, Human (Thioredoxin Reductase 2, Mitochondrial, Selenoprotein Z, SelZ, TR-beta, Thioredoxin Reductase TR3, TXNRD2, KIAA1652, TRXR2)

The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence(-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55

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SPECIFICATIONS

Catalog Number

T5010-16M

Size

500ug

Form

Supplied as a lyophilized powder from 20mM HEPES, pH 7.4. Reconstitute with sterile ddH2O.

Purity

~95% (SDS-PAGE)

References

1. Mustacich, D. and Powis,G. (2000) Biochem J. 15. 346 Pt 1:1-8.

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