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Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31)

Cat no: T3792-12

Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31)

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S riobsomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistance. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor-FoxM1.\n\nDMSO and DMF, partially soluble in methanol and ethanol while poorly soluble in water

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SPECIFICATIONS

Catalog Number

T3792-12

Size

5mg

Form

White solid

Purity

> 99% by HPLC

References

1. Thiostrepton, its salts and production Donovick R. 1961 US Patent 2982689 2. Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression. Chiu M.L. et al. J. Biol. Chem. 1999, 274, 20578. 3. Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et. al. Cancer Res. 2006, 19, 9731.

Alternative Names

Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31

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