THRA, ID (Thyroid Hormone Receptor alpha, Nuclear Receptor Subfamily 1 Group A Member 1, V-erbA-related Protein 7, EAR-7, c-erbA-1, c-erbA-alpha, EAR7, ERBA1, NR1A1, THRA1, THRA2)

Supplier:

United States Biological

Cat no: T5348-99E8

THRA, ID (Thyroid Hormone Receptor alpha, Nuclear Receptor Subfamily 1 Group A Member 1, V-erbA-related Protein 7, EAR-7, c-erbA-1, c-erbA-alpha, EAR7, ERBA1, NR1A1, THRA1, THRA2)

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410aa) (Nakai et al. 1988), TR alpha2 (490aa) ( Nakai et al. 1988), TR deltaalpha1 (~154aa), and TR deltaalpha2 (~237aa); however, only TR alpha1 is able to bind the ligand ( Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43kD, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003.\n\nApplications:\nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 0.5-1.5ug/ml\nImmunohistochemistry (Formalin fixed paraffin embedded): 3.75ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5348-99E8

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Additional Info

Recognizes human THRA. Species sequence homology: bovine, canine, mouse, porcine and rat.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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Reactivities

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