THRA (Thyroid Hormone Receptor alpha, Nuclear Receptor Subfamily 1 Group A Member 1, V-erbA-related Protein 7, EAR-7, c-erbA-1, c-erbA-alpha, EAR7, ERBA1, NR1A1, THRA1, THRA2)

Thyroid hormones regulate general metabolism and normal cellular growth and development. These actions are regulated by the thyroid hormone receptor (TR), a ligand-dependent transcriptional factor. At least two genes and several isoforms encode TR. Recent studies have implicated a role of TRs in thyroid hormone-induced apoptosis in larval tissues and proliferation of adult cell types.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 0.5-1,5ug/ml, observed in human bone marrow lysates on ~60+50kD bands\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5348-98N

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum, Mouse, Rat, Bov, Can, Prc

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Nishiyama K, Baba S, Yamada T, Matsushita A, Natsume H, Nakano K, Sasaki S, Nakamura H. Embryonic lethal effect of expressing a dominant negative mutant human thyroid hormone receptor alpha1 in mice. Endocr J. 2003 Oct;50(5):561-70.

Additional Info

Recognizes human THRA. Species sequence homology: Bovine, canine, mouse, porcine and rat.