THRB (Thyroid Hormone Receptor beta, Nuclear Receptor Subfamily 1 Group A Member 2, c-erbA-2, c-erbA-beta, ERBA2, NR1A2, THR1)

Thyroid hormone receptor beta (TR beta), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cholesterol metabolism, hearing, cone development in the eye, and hypothalamopituitary-thyroid axis function. Mice lacking the TR beta locus exhibit elevated thyroid hormone levels, profound hearing loss, impaired weight gain, abnormal bone development, and loss of thyroid-hormone induced activation of cholesterol 7 alpha-hydroxylase (CYP7A). Mutation in the ligand-binding domain of TR beta has been linked to the genetic disorder Resistance to Thyroid Hormone (RTH), and possibly to human cone disorders. Congenital thyroid disorders that impair hearing and result in profound deafness are common in geographic areas with a prevalence of iodine deficiency. Two human TR beta protein isoforms have been identified: TR beta1 (461aa), TR beta2 (476aa). Two additional protein isoforms, TR beta3 (390aa), and a non-DNA binding TR deltabeta3 (288aa), have been documented in rat.\n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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