Thrombin (HRP)

Supplier:

United States Biological

Cat no: T5045-10B

Thrombin (HRP)

Thrombin (EC3.4.21.5, alpha-thrombin) is the product of proteolytic activation of the zymogen prothrombin. Human thrombin is a two-chain serine protease with a mass of 37kD. The active site is located within the heavy chain. Thrombin has a high specificity for certain arginine bonds in protein substrates. The primary substrate is fibrinogen which thrombin converts to fibrin through the cleavage of four arginyl-glycyl peptide bonds. Thrombin is also an important activator of platelets, factor XIII, Protein C and TAFI (Plasma procarboxypeptidase B). In a positive feedback mechanism, thrombin increases the rate of its own production by activation of factors VIII and V. The rate of thrombin production is subsequently limited indirectly through the activation of Protein C by thrombin, which then inactivates the activated cofactors VIII and V. The binding of thrombin to thrombomodulin on the cell surface dramatically alters thrombin

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SPECIFICATIONS

Catalog Number

T5045-10B

Size

200ug

Applications

ELISA

Hosts

Sheep

Reactivities

Hum

Form

Supplied as a liquid in a buffered stabilizer solution, 50% glycerol. Labeled with horseradish peroxidase (HRP).

P Type

Pab

Purity

Purified

Isotype

IgG

References

1. Stubbs, M.T., et al., Thrombosis Research. 69: 1-58 (1993). 2. Mann, K.G., In: Hemostatis and Thrombosis, 3rd ed. Colman, R.W., et al., eds. pp.184-199, J.B. Lippincott Co., Philadelphia, PA, USA. 3. Downing, M.W., et al., Biochemistry 17: 2649-2653 (1978). 4. Weitz, J.I., et al., J. Clin. Invest. 86: 385-391 (1990).

Additional Info

Recognizes human thrombin or prothrombin.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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