Thrombopoietin Receptor (c-Mpl) (TPO)

Supplier:

United States Biological

Cat no: T5050-50

Thrombopoietin Receptor (c-Mpl) (TPO)

Thrombopoietin receptor (Tpo R), also known as myeloproliferative leukemia protein (c-mpl), is a 95kD type I transmembrane protein that is a member of the type I cytokine receptor family within the hematopoietin/cytokine receptor superfamily.\n\nApplications:\nSuitable for use in Western Blot, Immnohistochemistry and Immunoprecipitation. Other applications have not been tested.\n\nRecommended Dilutions:\nWestern Blot: 0.25-1ug/ml detects TPO receptor in RIPA lysates from DAMI cells. DAMI cell lysate was resolved by\nelectrophoresis, transferred to PVDF and\nprobed with T5050-50. Proteins were visualized using an IgG (HRP) goat anti-rabbit and a chemiluminescence detection system.\nImmunohistochemistry: Stains megakaryocytes in bone marrow biopsy sections.\nImmunoprecipitation: 5ug immunoprecipitates TPO receptor from 500ug of DAMI RIPA lysate.\nOptimal dilutions to be determined by the researcher. \n\nRecommended Secondary Antibodies: \nI1904-39: IgG, X-Adsorbed (HRP) Pab Gt xRb \nI1904-40A: IgG, H&L, X-Adsorbed (HRP) Pab Gt xRb \nI1904-46Q: IgG, H&L (HRP) Pab Gt xRb\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5050-50

Size

200ug

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.15M sodium chloride, 0.05% sodium azide, 30% glycerol.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Deng, B., et al., Blood 92: 1981-1988 (1998). 2. Moliterno, A., et al., New Eng. J. Med. 338: 572-580 (1998). 3. Moliterno, A. & Spivak, J.L., Blood 94: 2555-2561 (1999).

Additional Info

Recognizes glycosylated and unglycosylated human TPO receptor/c-Mpl, Mr 70kD. Species Crossreactivity: mouse

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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