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Thromboxane A2 Receptor (TBXA2R)

Cat no: T5120F

Thromboxane A2 Receptor (TBXA2R)

Thromboxane A2 (TXA2) is a potent vasoconstrictor and activator of platelet aggregation. The short half-life of TXA2 ensures local action whether generated by vascular endothelial cells or by platelets and confers physiologically beneficial or deleterious effects under inflammatory situations. TXA2 elicits its effects via a 7-transmembrane domain G protein-coupled receptor, the TP receptor.1 The TP receptor is highly expressed in platelets and is relatively less abundant in tissues such as lung, kidney, brain, spleen, thymus, monocytes, uterus, and placenta(3,4,5). The apparent molecular weight for TP receptors has been reported from 37-70 kD, depending on different degrees of glycosylation(6,5,7). However this antibody consistently detects the TP receptor at 55 and 64 kD in platelet, kidney, and Cos-7 cell samples. \n\nApplications:\nSuitable for use in ELISA, Western Blot, Immunocytochemistry and Immunofluorescence. Other applications not tested.\n\nRecommended Dilutions: \nWestern Blot: 5ug/ml\nImmunocytochemistry: 2ug/ml\nOptimal dilution to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5120F

Size

1Vial

Applications

ELISA, ICC, IF, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat, NHP

Form

Suppled as a liquid.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Hirata, M., et al., Nature 349 617-620 (1991). 2. Namba, T., et al., Biochem Biophys Res Commun 184 1197- 1203 (1992). 3. B

Additional Info

Recognizes human Thromboxane A2 Receptor. Species Crossreactivity: mouse, rat and Cos-7 (African green monkey).

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