Thymic Stromal Lymphopoietin (TSLP)

Supplier:

United States Biological

Cat no: T5150-04

Thymic Stromal Lymphopoietin (TSLP)

TSLP is a 159aa four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.\n\nApplications:\nSuitable for use in Immunohistochemistry and Western Blot. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (Paraffin): 4ug/ml\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHL60 cell lysate, human spleen and placenta\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5150-04

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, NHP

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide

P Type

Pab

Purity

Purified by immunoaffinity chromatography

Isotype

IgG

References

1. Rochman, I. et al. J. Immunol. 178:6720-6724 (2007). 2. Wang, YH. et al. J. Exp. Med. 204:1837-1847 (2007).

Additional Info

Recognizes human TSLP. Species Crossreactivity: chimpanzee and New World monkey.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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