Thymopentin (TP-5)

Thymopentin, also known as TP-5 is a synthetic derivative of thymopoietin, a thymic hormone, and has immunoregulatory properties. Thymopentin has a molecular formula of C30H49N9O9 H-Arg-Lys-Asp-Val-Tyr-OH having a Mw of 679.8.\n\nDimers and Aggregates: \nLess than 1% as determined by silver-stained SDS-PAGE gel analysis.\n\nEndotoxin: \n(same/less than) 0.1ng/ug (IEU/ug) of TP-5.\n\nProtein Content: \nProtein quantitation was carried out by two independent methods:\n1. UV spectroscopy at 280 nm.\n2. Analysis by RP-HPLC, using a calibrated solution of Thymopentin as a Reference Standard.\n\nSolubility: \nIt is recommended to reconstitute the lyophilized Thymopentin in sterile 18MOmega-cm H2O not less than 100microg/ml, which can then be further diluted to other aqueous solutions.\n\nStability: \nLyophilized Thymopentin although stable at room temperature for 3 weeks, should be stored desiccated below -180C. Upon reconstitution TP-5 should be stored at 40C between 2-7 days and for future use below -180C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

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SPECIFICATIONS

Catalog Number

T5219-90

Size

25mg

Form

Supplied as a lyophilized powder without additives.

Purity

(same/more than) 98% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Trypsin-catalyzed kinetically controlled synthesis of a precursor dipeptide of thymopentin in organic solvents, using a free amino acid as nucleophile.\n\nPrep Biochem Biotechnol 2004 Feb;34(1):45-56\n\n2. Increased radiation toxicity by enhanced apoptotic clearance of HL-60 cells in the presence of the pentapeptide thymopentin, which selectively binds to apoptotic cells.\n\nMutat Res 2004 Mar 14;558(1-2):19-26\n\n3. [Stability evaluation of thymopentin in preparation process]\n\nSichuan Da Xue Xue Bao Yi Xue Ban 2003 Apr;34(2):292-4\n\n4. [Therapeutic effects of Lamivudine in combination with Thymopentin on chronic hepatitis B]\n\nZhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2002 Dec;16(4):385-7\n\n5. [Modulating effects of thymopentin on the immune system of severely burned patients]\n\nZhonghua Shao Shang Za Zhi 2001 Oct;17(5):298-300\n\n6. Stimulation of nonspecific resistance by thymopentin and its analogs against Leishmania donovani infection in hamsters.\n\nPeptides 1999 Nov;20(11):1381-3