Thymosin, beta 4

Thymosin B4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. Extracellular Thymosin b4 may contribute to physiological processes such as angiogenesis, wound healing, and regulation of inflammation.\n\nAA sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T5225-05B

Size

1mg

Form

Supplied as a lyophilized powder without additives. Reconstitute in sterile ddH2O, 0.1% BSA or HSA to (same/more than) 0.1mg/ml, which can then be further diluted in other aqueous solutions.

Purity

(same/more than) 98% (RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel).

References

1. Possible functional involvement of thymosin beta 4 in developing tooth germ of mouse lower first molar. Histochem Cell Biol 2005 Sep;124(3-4):207-13. 2. A comparative analysis of RNA targeting strategies in the thymosin beta 4 gene. J Mol Biol 2004 Sep 24;342(4): 1069-76. 3. Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. J. Pharmacol Exp Ther 2004 Dec;311(3):885-91. 4. Overexpression of the thymosin beta-4 gene is associated with increased invasion of SW480 colon carcinoma cells and the distant metastasis of human colorectal carcinoma. Oncogene 2004 Aug 26;23(39):6666-71. 5. Assignment of the thymosin beta 4 X/Y chromosome (TMSB4X/Y) gene to tammar wallaby chromosome 5p by fluorescence in situ hybridisation. Cytogenet Genome Res 2003;103(1-2):203F. 6. Up-regulation of thymosin beta 4 gene expression in experimentally-induced uterine adenomyosis in mice. In Vivo 2003 Nov-Dec;17(6):561-5.