Thyroglobulin, Human (Tg)

Human Thyroglobulin (Tg) is a 660kD, dimeric protein produced by and used entirely within the thyroid gland. Human Thyroglobulin Tg was referred to as "colloid. Human Thyroglobulin (Tg)is used by the thyroid gland to produce the thyroid hormones thyroxine (T4) and triiodothyronine.\n\nPatients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against human Thyroglobulin (Tg). Human Thyroglobulin Tg-specific antibodies help in the diagnosis of these diseases, but they also may be present in apparently healthy euthyroid individuals.\n\nHuman Thyroglobulin (Tg)levels in the blood can be used as a tumor marker for certain kinds of thyroid cancer. Thyroglobulin (Tg) levels in the blood can also be elevated in cases of Graves disease.\n\nApplications:\nSuitable for use as a standard in immunoassay for determination of serum thyroglobulin levels, immunogen for antisera production, tracer for iodination.\nOther applications have not been tested.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T5300-08B

Size

1mg

Form

Supplied as a lyophilized powder from 0.02M NH4HCO2. May contain traces of buffer salts. Reconstitute with PBS, 0.15M sodium chloride, pH 7.0.

Purity

(same/more than) 98% by SDS-PAGE. Immunological identity confirmed by reaction with monoclonal antibody that is specific for the human thyroglobulin.

References

1 Clinical Endocrinology Volume 66 Issue 1. Page 58.January 2007/2. Clin Chem Lab Med. 2006;44(5): 648.Clin Endocrinol Metab. 2007Apr;92(4):1451-7 4.Cancer. 2007 Mar 15;109(6):1078-81 Endocrine Abstracts (2007) 13 P224/human/thyroglobulin 5.Exp Clin Endocrinol Diabetes 2006; 114 6.Life Sci. 2007 Jan 16;80(6):538-45 7.:J Clin Endocrinol Metab. 2007 Apr;92(4):1451-7 8.Clinical Biochemistry, Volume 40, ( 9-10), June 2007: 735-738 9.Journal of Autoimmunity, Volume 28, Issue 4, June 2007, Pages 171-176 10.Clinica Chimica Acta, Volume 379, Issues 1-2, April 2007, 101-104 11Clinica Chimica Acta, Volume 374, Issues 1-2, December 2006.