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Thyroglobulin (Tg)

Cat no: 138596

Thyroglobulin (Tg)

Thyroglobulin is a 660kD dimeric preprotein with mutiple glycosylation sites is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformation maturation in the endoplasmic reticulation. Thyroglobulin dimerization as well as transport of thyroglobulin to the Golgi complex is calcium dependent. Thyroglobulin defects resulting from defective dimer formation and export to the Golgi is thought to cause some types of goiter. Antibody against thryoglobulin may be produced by individuals with other diseases arising from the gland such as Hashimoto

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SPECIFICATIONS

Catalog Number

138596

Size

20ug

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

1. He XX, VP Antao, D Basila. Blood 79:2296-2302 (1992) 2. Lanza F, L Healy, DR Sutherland. J Biol Reg Homeost Agents 15:1-13 (2001).

Additional Info

Recognizes human thyroglobulin.

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