Thyroglobulin (Tg)

Thyroglobulin is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin, a large glycoprotein with multiple tyrosyl molecules, is the storage form of thyroid hormone and is found in the follicular lumen of the thyroid cell. Coupling of iodotyrosine molecules within thyroglobulin forms the thyroid hormones T3 (triiodothyronine) and T4 (tetraiodothyronine). It is made up of 8301-nucleotide segment encoding a preprotein monomer of 2767aa, flanked by non-coding 5' and 3' regions of 41 and 106 nucleotides, respectively. It is expressed in thyroid gland and maps to 8q24 region of human chromosome. Its defects results in some forms of goitre.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 1:25-1:50\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nThyroid\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5300-01K

Size

500ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid, 0.05% sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG2a

References

1. Chan et al. Clin Exptl Immunol 70:516, 1987. 2. Male et al. Immunology 54: 419, 1985. 3. Shepherd et al. Europ J Nucl Med 10: 291, 1985. 4. Malthiery et al. Eur J Biochem 165: 491, 1987.

Additional Info

Recognizes human Thyroglobulin.