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TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)

Cat no: T5498-45

TIA1 (Cytotoxic Granule-associated RNA binding protein, Nucleolysin TIA-1 isoform p40, p40-TIA-1, T-cell-restricted intracellular antigen-1, RNA-binding protein)

TIA-1 (T-cell intracytoplasmic antigen) monoclonal antibody reacts with a 15kD cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. The expression of TIA-1 was studied in CD30+ anaplastic large cell lymphomas (ALCL), NK cell lymphomas and peripheral T-cell lymphomas and T cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, Hodgkins, etc. Studies showed that 60 to 70% of anaplastic large cell lymphoma reacted with TIA-1. Studies also indicate that TIA-1 reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas, pulmonary angiocentric lymphomas of T or NK phenotype. The authors concluded from TIA-1 studies that anaplastic large-cell lymphomas are cytotoxic T-or NK-cell neoplasms. All B-cell lymphomas, Hodgkins and lymphoblastic leukemias were negative for TIA-1 (1). \n\nApplications: \nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilutions:\nImmunohistochemistry (paraffin): 1:50-1:100. Incubate for 30-60 minutes at RT. Use heat-mediated antigen retrieval; an optional pepsin treatment can also improve the signal. \nOptimal dilutions to be determined by the researcher.\n\nPositive Control:

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SPECIFICATIONS

Catalog Number

T5498-45

Size

250ul

Applications

IHC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in proprietary buffer with protein carrier and sodium azide.

P Type

Mab

Purity

Supernatant

Isotype

IgG1

Additional Info

Recognizes human TIA 1.

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