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TIA1 (Nucleolysin TIA-1 Isoform p40, RNA-binding Protein TIA-1, T-cell-restricted Intracellular Antigen-1, TIA-1, p40-TIA-1)

TIA1 (Nucleolysin TIA-1 Isoform p40, RNA-binding Protein TIA-1, T-cell-restricted Intracellular Antigen-1, TIA-1, p40-TIA-1)

Cat no: T5498-45B

Supplier: United States Biological
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The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15kD protein that is thought to be derived from the carboxyl terminus of the 40kD product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:128,000 Western Blot: 0.1-0.3ug/ml, observed in lysates of cell line Jurkat on ~40kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T5498-45B
Reactivities: Human, Mouse, Rat, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Yang F, Peng Y, Murray EL, Otsuka Y, Kedersha N, Schoenberg DR. Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1. Mol Cell Biol. 2006 Dec;26(23):8803-13. Epub 2006 Sep 18.
Additional info: Recognizes human TIA1. Species sequence homology: Canine, mouse and rat.

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