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TIAF1, Recombinant, Human, aa1-115, His-Tag (TGFB1-induced Anti-apoptotic Factor 1, MAJN, SPR210)

Cat no: 138758

TIAF1, Recombinant, Human, aa1-115, His-Tag (TGFB1-induced Anti-apoptotic Factor 1, MAJN, SPR210)

TGFB1-induced anti-apoptotic factor 1, also known as TIAF1, inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. This protein involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. \n\nSource:\nRecombinant protein corresponding to aa1-115 from human TIAF1 at N-terminal, fused to His-tag expressed in E.coli. \n\nMolecular Weight: \n~16.6kD (152aa)\n\nAA Sequence:\nMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSH\nCGPSAPPAPT PPSLSQRVMC NDLFKVNPFQ LQQFRADPST ASLLLCPGGL DHKLNLRGKA WG MSS PSSPFREQSF LCAAGDAGEE SRVQVLKNEV RRGSPVLLGW VEQAYADKCV\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

138758

Size

50ug

Form

Supplied as a liquid in 20mM tris-HCl buffer, pH 8.0, 0.4M urea, 10% glycerol.

Purity

~85% (SDS-PAGE)

References

1. Chang N.-S., et al. (1998) Biochem. Biophys. Res. Commun. 253:743-749 2. van der Leij J., et al. (2003) Transplantation. 75:2076-2082.

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