TIGAR, NT (TIGAR, C12orf5, Fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator) (APC)

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq].\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

042832-APC

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Mouse

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Bensaad, K., et al. EMBO J. 28(19):3015-3026(2009)\nTrevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)\nLopez-Guerra, M., et al. Haematologica 93(12):1843-1851(2008)\nMatsuoka, S., et al. Science 316(5828):1160-1166(2007)\nBensaad, K., et al. Cell 126(1):107-120(2006)

Additional Info

Mouse

Alternative Names

TIGAR, C12orf5, Fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator