TIM3 (Hepatitis A Virus Cellular Receptor 2, HAVcr-2, T-cell Immunoglobulin and Mucin Domain-containing Protein 3, TIMD-3, T-cell Membrane Protein 3, TIM-3, HAVCR2, TIMD3) (PerCP)

Mouse Tim-3 (T-cell Immunoglobulin- and Mucin -domain- containing molecule -3) is a type I transmembrane protein that contains an immunoglobulin V-type domain followed by a mucin-like domain in its extracellular region.1 Tim-3 is expressed on Th1 and Tc1 cells and is hypothesized to regulate macrophage activation.1 Binding of Tim-3 to Tim-3 Ligand on CD4+ T cells suggests that these proteins function in regulating Th1 cell expansion and/or activation,2 and suggests a role for Tim-3 in inducing tolerance.3 Mouse models utilizing antibodies to Tim-3 reveal a role for Tim-3 in immune-mediated diseases such as asthma and multiple sclerosis.2, 4\n\nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nHybridoma: \nMyeloma cells with B cells from Balb/c mice.\n\nAbsorption: 482-564nm\n\nEmission: 675nm\n\nStorage and Stability:\nMay be stored at 4 degrees C. For long-term storage, aliquot and store at 4 degrees C. Do not freeze. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. PerCP conjugates are sensitive to light.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

T5469-92R

Size

100Tests

Hosts

Rat

Reactivities

Mouse

Form

Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with PerCP.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG2A

References

1. Monney, L. et al. (2002) Nature 415:536. 2. Sabatos, C. et al. (2003) Nat. Immunol. 4:1102. 3. Sanchez-Fueyo, A. et al. (2003) Nat. Immunol. 4:1093. 4. McIntire, J. et al. (2001) Nat. Immunol. 2:1109.

Additional Info

Recognizes mouse TIM-3.