TIMP-3 Antibody

Cat no: 252643

Supplier: ABBIOTEC

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Description
Additional Information

TIMP-3 (Tissue inhibitor of metalloproteinases 3) is a secreted e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian, protein,Mouse,etalloprotease inhibitor. It forms comple, Xenopus/Amphibian,es with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. TIMP-3 is critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors and by inhibiting protease activity in tissues undergoing remodelling of the e, Xenopus/Amphibian,tracellular matri, Xenopus/Amphibian,. Defects in TIMP-3 are the cause of Sorsby fundus dystrophy (SFD). SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally,Mouse,acular disciform degeneration develops in the patient

Catalogue number:	252643
Reactivities:	Human
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P35625
Antigen:	Purified recombinant fragment of human TIMP-3 e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	Metalloproteinase inhibitor 3; Tissue inhibitor of metalloproteinases 3; TIMP-3; Protein MIG-5; TIMP3