$TIMP1, Recombinant, Human (Metalloproteinase Inhibitor 1, Erythroid-potentiating Activity, EPA, \nFibroblast Collagenase Inhibitor, Collagenase Inhibitor Tissue Inhibitor of Metalloproteinases 1, TIMP-1, CLGI, TIMP)$

Supplier:

Cat no: 149568

TIMP1, Recombinant, Human (Metalloproteinase Inhibitor 1, Erythroid-potentiating Activity, EPA, \nFibroblast Collagenase Inhibitor, Collagenase Inhibitor Tissue Inhibitor of Metalloproteinases 1, TIMP-1, CLGI, TIMP)

TIMP1 is an extracellular inhibitor of MMPs (see above) including MMP1, 2, 3, 7, 8, 9, 10, 11, 12, 13, and 16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors. Recombinant human TIMP-1 is a 20.6kD protein containing 184aa.\n\nSource:\nRecombinant protein corresponding to human TIMP-1, expressed in E. coli.\n\nBiological Activity:\nTIMP1 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5ug/ml, when using an MMP-1 concentration of 1.6ug/ml.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nCTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts