Timp2 (Tissue Inhibitor of Metalloproteinase 2, timp2a)

Tissue inhibitors of metalloproteinases (TIMPs) are involved in the control of matrix-metalloproteinase (MMP) activity as a key inhibitor in tissue. Expression of MMPs and TIMPs are controlled during tissue remodeling to maintain a balance in the regulation of extracellular matrix turnover and other morphogenic processes. TIMP-2 has also been reported to have growth factor properties. Zebrafish TIMP-2 shows high similarity to human TIMP-2 with all critical features conserved. Immunoreactive zebrafish TIMP-2 was detected at the protein level with a recombinant antibody for human TIMP-2. TIMP-2 was shown to be expressed as early as the one cell stage, and blockage of TIMP-2 translation resulted in abnormal zebrafish development.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:16,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T5585-10W

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

ZF/Fish

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Zhang J, Bai S, Tanase C, Nagase H, Sarras MP Jr. The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol. 2003 Aug;213(8):382-9. Epub 2003 May 8.

Additional Info

Recognizes Timp2. Species sequence homology: Zebrafish.