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Timp2 (Tissue Inhibitor of Metalloproteinase 2, timp2a)

Timp2 (Tissue Inhibitor of Metalloproteinase 2, timp2a)

Cat no: T5585-10W

Supplier: United States Biological
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Tissue inhibitors of metalloproteinases (TIMPs) are involved in the control of matrix-metalloproteinase (MMP) activity as a key inhibitor in tissue. Expression of MMPs and TIMPs are controlled during tissue remodeling to maintain a balance in the regulation of extracellular matrix turnover and other morphogenic processes. TIMP-2 has also been reported to have growth factor properties. Zebrafish TIMP-2 shows high similarity to human TIMP-2 with all critical features conserved. Immunoreactive zebrafish TIMP-2 was detected at the protein level with a recombinant antibody for human TIMP-2. TIMP-2 was shown to be expressed as early as the one cell stage, and blockage of TIMP-2 translation resulted in abnormal zebrafish development. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T5585-10W
Reactivities: Zebrafish/Fish
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhang J, Bai S, Tanase C, Nagase H, Sarras MP Jr. The expression of tissue inhibitor of metalloproteinase 2 (TIMP-2) is required for normal development of zebrafish embryos. Dev Genes Evol. 2003 Aug;213(8):382-9. Epub 2003 May 8.
Additional info: Recognizes Timp2. Species sequence homology: Zebrafish.

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