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TINAGL1 (Tubulointerstitial Nephritis Antigen-like 1, GIS5, LCN7, LIECG3, OLRG2, P3ECSL, TIN-ag-RP)

Cat no: 145627

TINAGL1 (Tubulointerstitial Nephritis Antigen-like 1, GIS5, LCN7, LIECG3, OLRG2, P3ECSL, TIN-ag-RP)

TINAGL1 (Tubulointerstitial nephritis antigen-like 1; also TIN-ag-RP, AZ-1 and LCN7) is a 54-57kD glycoprotein member of the peptidase C1 family of molecules. It is secreted by renal tubule epithelium, zona glomerulosa cells, vascular smooth muscle and striated muscle cells. TINAGL1 may play a role in the spatial and temporal development of the steroid component of the adrenal, in part by suppressing the expression of CYP11B1. Human TINAGL1 is synthesized as a 467 amino acid (aa) precursor. It contains a 21 a signal sequence and a 446aa mature region (aa22-467). Within the mature region is an SMB (somatomedin B) domain (aa50-98), one vWFC domain (aa105-140), and a nonenzymatic peptidase C1A region (aa204-455). There are multiple potential isoform variants. One contains an alternative start site at aa106, another shows a deletion of aa126-156, and a third possesses a 60 aa substitution for aa1-194, coupled to a 38aa insertion after aa286, and a 16aa substitution for aa365-467. Undefined forms of 40-42kD and 22kD have been noted in TINAGL1

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SPECIFICATIONS

Catalog Number

145627

Size

100ug

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder in PBS, Trehalose. Reconstitute in sterile PBS.

P Type

Mab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human TINAGL1 in direct ELISAs and Western blots.

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