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TIP30, aa1-242, Recombinant, Human (30kD HIV-1 TAT-interacting Protein, CC3, FLJ26963, HIV-1 TAT-interactive Protein 2, Oxidoreductase HTATIP2, SDR44U1, HTATIP2)

Cat no: T5499-86H

TIP30, aa1-242, Recombinant, Human (30kD HIV-1 TAT-interacting Protein, CC3, FLJ26963, HIV-1 TAT-interactive Protein 2, Oxidoreductase HTATIP2, SDR44U1, HTATIP2)

HTATIP2, also known as TIP30, is a member of the short-chain dehydrogenases/reductases (SDR) family. It acts as a tumor suppressor participating in metabolic suppression, inhibition of angiogenesis and induces the expression of apoptosis related genes Bad and Siva. HTATIP2 interacts with the activation domain of HIV-1 TAT and enhances its transcription by phosphorylating RNA polymerase II (Pol II). Defects in This protein are associated with hepatocellular carcinomas and apoptotic resistant tumor cells, suggesting a potential use for HTATIP2 in antitumor therapy. \n\nSource:\nRecombinant corresponding to aa1-242 of human 6x HTATIP2 his tagged, expressed in E.coli. \n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MAETEALSKL REDFRMQNKS VFILGASGET GRVLLKEILE QGLFSKVTLI GRRKLTFDEE AYKNVNQEVV DFEKLDDYAS AFQGHDVGFC CLGTTRGKAG AEGFVRVDRD YVLKSAELAK AGGCKHFNLL SSKGADKSSN FLYLQVKGEV EAKVEELKFD RYSVFRPGVL LCDRQESRPG EWLVRKFFGS LPDSWARGHS VPVVTVVRAM LNNVVRPRDK QMELLENKAI HDLGKAHGSL KP\n\nMolecular Weight: 29.3kD (262aa), confirmed by MALDI-TOF\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T5499-86H

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 1mM DTT.

Purity

~95% (SDS-PAGE).

References

1. Shtivelman E., et al. (1997) Oncogene. 14(18):2167-73. 2. Xiao H., et al. (1998) Proc Natl Acad Sci USA. 95(5):2146-2151.

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