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TIPRL (TIP41-like Protein, Putative MAPK-activating Protein PM10, Type 2A-interacting Protein, TIP)

TIPRL (TIP41-like Protein, Putative MAPK-activating Protein PM10, Type 2A-interacting Protein, TIP)

Cat no: T5499-88C

Supplier: United States Biological
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May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:16,000 Western Blot: 1-3ug/ml, lysates of cell line K562 observed on ~30kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T5499-88C
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Ehret GB, O'Connor AA, Weder A, Cooper RS, Chakravarti A, Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. Eur J Hum Genet. 2009 Dec;17(12):1650-7.
Additional info: Recognizes human TIPRL. Species sequence homology: Bovine, canine, mouse and rat.

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