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Tissue Array, Human, BioAssay(TM) Bladder carcinoma, transitional cell carcinoma, grade I~III with normal

Cat no: T5596-1461


Supplier: United States Biological
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Pre-developed human tissue arrays can be used to survey hundreds or even thousands of clinical specimens in a single experiment using common probes, such as DNA, RNA, peptide, protein and antibodies. Tissue arrays permit for a rapid and large-scale molecular analysis of tissue specimens with various probes in parallel. This powerful technique can be employed for verification and validation of gene discoveries and identification of potential diagnostic and therapeutic targets. It provides an effective assessment of the clinical significance of the molecular targets in cancer and other diseases at cellular and tissue levels. It is in situ and in vivo assay providing great clinical relevance. Tissue chip lines bridge the gap between genomics and drug discovery, and effectively decrease time and cost of drug discovery processes. Cores/Cases 63/60 Each single tissue core on every array slide is individually examined by pathologists certified according to WHO published standardizations of diagnosis, classification and pathological grade. Pathological re-confirmation report is generated and digital image captured. Before the array products are delivered to clients, standard immunohistochemistry tests and in situ hybridization tests are also performed to ensure the accuracy and specificity of tissue array products. Neutral formalin-fixation and paraffin-embedding procedures have been applied to all specimens obtained from clinics. Consequently, no living organism would exist on any paraffin-embedded arrays. Each specimen collected from any clinic was consented to by both hospital and individual. Discrete legal consent form was obtained and the rights to hold research uses for any purpose or further commercialized uses were waived.
Catalogue number: T5596-1461
Reactivities: Human
Applications: Immunohistochemistry
Size: 1 Array
References: 1. Kazuhiko Mishima, et al. Increased expression of podoplanin in malignant astrocytic tumors as a novel molecular marker of malignant progression. Acta Neuropathol March (2006). (paper). 2. Mohammad Saleem, Vaqar Mustafa Adhmai, Weixiong Zhong, B. Jack Longley, Chen-Yong Lin, Robert B. Dickson, Shannon Reagan-Shaw, David F. Jarrard, and Hasan Mukhtar. A novel biomarker for staging human prostate adenocarcinoma: Overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activiator inhibitor-1. Cancer Epidemiol Bioimarker Prev 15(2) 217-227, February (2006). (paper) 3. Chen-Feng Qi, et al. Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B-cell lymphomas. Leukemia Research (30) 153-163, February (2006). (paper). 4. Tin Lab Lee, et al Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Mol Cancer Ther 5(1) 8-19, January (2006). (paper) 5. N Chen, et al Tumor-suppression function of transcription factor USF2 in prostate carcinogenesis. Oncogene 1-9 (2005) (paper). 6. Ming Li, et al. Overexpression of 5-Lipoxygenase and Cyclooxygenase2 in Hamster and Human Oral Cancer and Chemopreventive Effects of Zileuton and Celecoxib. Clinical Cancer Research Vol. 11, 2089-2096, (2005). (paper). 7. Min Yan, et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGFg induced suppressor of human gastrointestinal cancers. PNAS Vol.101, No. 50, 17468-17473 (2004). (paper) 8. Luping Wang, et al. Extracellular matrix protein1 (ECM1) is over-expressed in malignant epithelial tumors. Cancer Letter Vol. 200 75-67 (2003) (paper). 9. Holger Moch, Jet al , Tissue microarrays: what will they bring to molecular and anatomic pathology. Advances in Anatomic Pathology Vol.8, No.1,14-20, (2001). 10. Ronald Simon, Jan Richter, Urs Wagner, et al., High-throughput tissue microarray analysis of 3p25 (RAF1) and 8p12 (FGFR1) copy number alterations in urinary bladder cancer. Cancer Res. 61:4514-4519, (2001). 11. Mark A. Rubin. Use of laser capture microdissection, cDNA microarrays, and tissue microarrays in advancing our understanding of prostate Cancer. J. Pathol. 195:80-86, (2001). 12. Olli-P. Kallioniemi, Urs Wagner, Juha Kononen and Guido Sauter, Tissue microarray technology for high-throughput molecular profiling of cancer. Human Molecular Genetics Vol.10, No.7, 657-662, (2001). 13. David L. Rimm, Robert L. Camp, Lori A.Charette, et al., Tissue microarray: a new technology for amplification of tissue resources. The Cancer Journal Vol.7, No.1, (2001). 14. Lukas Bubendorf, Antonio Nocito, Holger Moch and Guido Sauter, Tissue microarray (TMA) technology: miniaturized pathology archives for high -Throughput in situ studies. J. Pathol. 195:72-79, (2001). 15. Chad R. Englert, Galina V. Baibakov, and Michael R. Emmert-Buck, Cancer Res. 60:1526-1530, (2000). 16. F. von Eggeling, H. Davies, L. Lomas, W. Fiedler, K. Junker, U. Claussen and G. Ernst, Tissue-specific microdissection coupled with proteinchip array technologies: applications in cancer research. Biotechniques Vol.29, No.5, 1066-1070, (2000). 16. Olivier Braissant and Walter Wahli, A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections. Biochemica No.1, 10-16, (1998).

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