Tissue Inhibitor of Metalloproteinases 4 (TIMP4)

Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (~23kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7. 1-9\n\nApplications:\n

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SPECIFICATIONS

Catalog Number

T5589-04B

Size

100ug

Applications

IHC, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 100mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.

P Type

Mab

Purity

Purified

Isotype

IgG2a

References

1. Greene, J., M. Wang, Y.E. Liu, L.A. Raymond, C. Rosen, and Y.E. Shi. 1996. J. Biol. Chem. 271:30375.\n2. Liu, Y.E., M. Wang, J. Greene, J. Su, S. Ullrich, H. Li, S. Sheng, P. Alexander, Q.A. Sang, and Y.E. Shi. 1997. J. Biol. Chem. 272:20479.\n3. Chesler, L., D.W. Golde, N. Bersch, and M.D. Johnson. 1995. Blood 86:4506.\n4. Stetler-Stevenson, W.G., N. Bersch, and D.W. Golde. 1992. FEBS Lett. 296:231.\n5. Corcoran, M.L., and W.G. Stetler-Stevenson. 1995. J. Biol. Chem. 270:13453.\n6. Hayakawa, T., K. Yamashita, E. Ohuchi, and A. Shinagawa. 1994. J. Cell Sci. 107:2373.\n7. Leco, K.J., S.S. Apte, G.T. Taniguchi, S.P. Hawkes, R. Khokha, G.A. Schultz, and D.R. Edwards. 1997. FEBS Lett. 401:213.\n8. Dollery, C.M., J.R. McEwan, M. Wang, Q.A. Sang, Y.E. Liu, and E. Shi. 1999. Circ. Res. 84:498.\n9. Tummalapalli, C.M., B.J. Heath, and S.C. Tyagi. 2001. J. Cell. Biochem. 80:512.

Additional Info

Recognizes human TIMP-4.