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Tissue Plasminogen Activator (tPA) (HRP)

Cat no: T5600-05A

Tissue Plasminogen Activator (tPA) (HRP)

Tissue-type plasminogen activator (tPA) is one of two major physiologic activators of plasminogen in plasma. It is a serine protease of 68kD produced primarily in endothelial cells. it is also present in monocytes and megakaryocytes. Normal plasma tPA antigen concentrations have been reported from 20ng/ml-5ug/ml, depending on the assay used, but typically most of the tPA (> 90%) is in complex with it

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SPECIFICATIONS

Catalog Number

T5600-05A

Size

200ug

Applications

ELISA

Hosts

Sheep

Reactivities

Hum

Form

Supplied as a liquid in a buffered stabilizer solution with 50% glycerol. Labeled with horseradish peroxidase (HRP).

P Type

Pab

Purity

Purified

Isotype

IgG

References

1.Bachmann, F.: The Plasminogen-Plasmin Enzyme System; in Hemostasis and Thrombosis, 3rd Edition, eds. R.W. Colman, J. Hirsh, V.J. Marder, E.W. Salzman, pp. 1592-1622, J.B. Lippincott Co., Philadelphia PA, USA (1994). 2. Holvoet, P., Cleemput, H., Collen, D.: Assay of Human Tissue-Type Plasminogen Activator (t-PA) with an Enzyme-Linked Immunosorbent Assay (ELISA) Based on Three Murine Monoclonal Antibodies to t-PA. Thrombosis and Haemostasis 54: 684-687 (1985). 3. Giles, A.R., Nesheim, et al.: The fibrinolytic Potential of the Normal Primate following the Generation of Thrombin In Vivo. Thrombosis and Haemostasis 63: 476-481 (1990).

Additional Info

Recognizes human Tissue Plasminogen Activator (tPA). Identity was verified using purified tPA.

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