Tissue, Section, Human Disease, Parkinson, Brain, Pons (Frozen)

Parkinson's disease (also known as Parkinson disease or PD) is a degenerative disease of the brain (central nervous system) that often impairs motor skills, speech, and other functions. Parkinson's disease belongs to a group of conditions called movement disorders. It is characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physical movement (akinesia). The primary symptoms are the results of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Secondary symptoms may include high level cognitive dysfunction and subtle language problems. PD is both chronic and progressive. PD is the most common cause of chronic progressive Parkinsonism, a term which refers to the syndrome of tremor, rigidity, bradykinesia and postural instability. PD is also called primary parkinsonism or idiopathic PD (classically meaning having no known cause although many genetic mutations associated with PD have since been discovered). While many forms of parkinsonism are idiopathic, secondary cases may result from toxicity most notably of drugs, head trauma, or other medical disorders.\n\nTissues were snap frozen in liquid nitrogen immediately after excision, and embedded in OCT. All frozen tissue products, including frozen tissue arrays, frozen tissue sections, and frozen tissue panels, can be used for both immunohistochemistry and in situ hybridization. These products are ideal for rapid cellular localization of RNA and protein expression, especially for antibodies that don't recognize paraffin embedded tissue. At least one of the tissue slides from each lot was stained with H & E to ensure the quality.\n\nThe tissue sections are 5-10um in thickness, mounted on positively charged glass slides, and fixed by cold acetone.\n\nShelf Life: Half a year from the date of receipt under proper storage condition\n\nRelated Products:\nHuman Frozen Tissue Section Matched Pairs (PP/PM):\nHuman frozen tissue section matched pair products include: Primary Pair (PP), Primary and metastatic Pair. PP consists of frozen tissue sections of primary tumor (or diseased tissue) and its adjacent normal tissue; PM consists of frozen tissue sections of primary tumor and corresponding metastatic tumor. Frozen tissue sections in each pair are prepared from the same donor. This product line is ideal for localization of tumor-specific (or disease specific) genes and tumor metastatic genes. Tissue sections are 5-10um in thickness, mounted on positively charged glass slides, and fixed by cold acetone.\n\nFrozen Tissue Section Panel:\nFrozen Tissue Section Panel contains 5 to 8 different tissues on one slide. The tissue panels are 5-10um in thickness, mounted on positively charged glass slides, and fixed by cold acetone.\n\nFrozen Tissue Array:\nFrozen Tissue Array contains up to 45 tissue spots from different tissues on one slide. Each tissue core size is 2 mm diameter. Tissue arrays are 5-8um in thickness, mounted on positively charged glass slides, and fixed by cold acetone. A reference chart shows all the tissue names and their respective position on the array.

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