TL1A (Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, Vascular Endothelial Cell Growth Inhibitor, TNFSF15, VEGI)

TL1A, also known as TNF ligand-related molecule 1, vascular endothelial growth inhibitor, and TNF ligand superfamily member 15, is a type II membrane protein with a predicted molecular weight of 28kD. TL1A can also be found as a secreted protein as a result of proteolytic cleavage with a reported molecular weight of 32kD. TL1A is a ligand for DR3 and DcR3 and is highly expressed in endothelial cells TL1A expression has also been observed in kidney, lung, prostate, placenta, and liver. Expression of TL1A is inducible with TNF and IL-1a (but not IFN-G). TL1A acts to inhibits endothelial cell growth and has been reported to induce endothelial cell apoptosis and inhibit neovascularization in tumors. In lymphocytes, TL1A has been shown to enhance IL-2 receptor a and B expression and increase IL-2 induced proliferation and secretion of IFN-y and GM-CSF. This antibody has been reported to enhance endothelial cell proliferation, motility and migration, and induce the formation of tube networks.\n\nApplications:\nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8038-07B

Size

100ug

Applications

IP, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1,k

References

1. Migone, T.S., et al. 2002. Immunity 16:479. 2. Tan, K.B., et al. 1997. Gene 204:35. 3. Zhai, Y., et al. 1999. FASEB J. 13:181. 4. Yue, T.-L., et al. 1999. J. Biol. Chem. 274:1479. 5. Yang, CR., et al. 2004. Cancer Res. 64:1122.

Additional Info

Recognizes human TL1A.