TLR11 (Toll-like Receptor 11, Gm287)

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.\n\nApplications:\nSuitable for use in Flow Cytometry and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 2-3ug/ml\nFlow Cytometry (intracellular): 0.5-1ug/10e6 calls\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8051-10H

Size

100ug

Applications

FC, WB

Hosts

Rabbit

Reactivities

Mouse, Rat

Form

Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998). . Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). 3. Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,Mudd,S., Shamel,L.,Sovath,S., Goode,J., Alexopoulou,L.,Flavell,R.A. and Beutler,B. Proc. Natl. Acad. Sci. U.S.A. 101 (10), 3516-3521 (2004).

Additional Info

Recognizes mouse TLR11. Species Crossreactivity: rat.