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TLR2 (Toll Like Receptor 2, CD282) (Biotin)

TLR2 (Toll Like Receptor 2, CD282) (Biotin)

Cat no: T8050-09Q

Supplier: United States Biological
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Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of gram-negative bacteria, several whole gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. Applications: Suitable for use in Immunohistochemistry, Immunoassays, and Flow Cytometry. Not suitable for Western Blot or Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin-embedded and frozen sections): 1:50 Flow Cytometry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-09Q
Reactivities: Mouse
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry
Conjugates: Biotin
Size: 50ug
Form: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. Labeled with Biotin.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
Alternative names: TLR2, CD282
References: 1. Meng, G et al; Murine TLR2 expression analysis and systemic antagonism by usage of specific monoclonal antibodies. Immunology Letters 2005, 98: 200
Additional info: Recognizes mouse native TLR2 protein and not with denatured TLR2 protein. mT2.4 inhibits murine TLR2-mediated cell activation. It masks the lipopeptide binding site in recombinant TLR2ECD and does not hindrance the receptor complex formation. It stains overexpressed, as well as endogenous cell surface- and intracellular mouse TLR2.

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