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TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282, CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein 4, TIL4)

TLR2 (Toll Like Receptor 2, Toll-like Receptor 2 Precursor, TLR 2, TLR-2, CD282, CD282 Antigen, Toll/interleukin 1 Receptor-like 4, Toll/interleukin Receptor-like Protein 4, TIL4)

Cat no: T8050-11F

Supplier: United States Biological
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TLR is a member of the Toll-like receptor (TLR) family and is expressed primarily by peripheral blood monocytes.TLRs are expressed on the cell surface and the endocytic compartment and recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents.They also initiate cell signalling to induce production of cytokines necessary for the innate immunity and subsequent adaptive immunity. TLR2 is reported to respond to a diverse range of bacterial cell wall components, mediating the innate immune response in co-operation with MD-2. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry (frozen), and Immunoprecipitation. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10-1:50; 10ul labels 10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Hybridoma: NSO myeloma cells with spleen cells from Balb/c mice. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8050-11F
Reactivities: Human, Canine, Non-Human Primate
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Size: 100ug
Form: Supplied as a liquid in PBS, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified
References: 1. Lien, E. et al. (1999) Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 274: 33419 - 33425. 2. Flo, T. H. et al. (2001) Differential expression of toll-like receptor 2 in human cells. J. Leukoc. Biol. 69: 474 - 481.
Additional info: Recognizes human TLR2. Species crossreactivity: Marmoset, Cynomolgus monkey, Rhesus Monkey, canine. Reported to block TLR2 function.

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